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Comb Chem High Throughput Screen. 2019;22(2):78-88. doi: 10.2174/1386207322666190325115526.

Progress in Molecularly Imprinted Polymers for Biomedical Applications.

Author information

1
Department of Mechanical Engineering, University of British Columbia, 2054-6250 Applied Science Lane, Vancouver, BC V6T 1Z4, Canada.
2
Centre for Blood Research, Life Sciences Centre, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.
3
Department of Chemical and Petroleum Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB, T2N 1N4, Canada.
4
Faculty of Medicine, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.

Abstract

BACKGROUND:

Molecularly Imprinted Polymers (MIPs), a type of biomimetic materials have attracted considerable interest owing to their cost-effectiveness, good physiochemical stability, favorable specificity and selectivity for target analytes, and long shelf life. These materials are able to mimic natural recognition entities, including biological receptors and antibodies, providing a versatile platform to achieve the desirable functionality for various biomedical applications.

OBJECTIVE:

In this review article, we introduce the most recent development of MIPs to date. We first highlight the advantages of using MIPs for a broad range of biomedical applications. We then review their various methods of synthesis along with their latest progress in biomedical applications, including biosensing, drug delivery, cell imaging and drug discovery. Lastly, the existing challenges and future perspectives of MIPs for biomedical applications are briefly discussed.

CONCLUSION:

We envision that MIPs may be used as potential materials for diverse biomedical applications in the near future.

KEYWORDS:

Molecularly imprinted polymers; antibodies; biomedical applications; biosensing; cell imaging; drug discovery.; drug delivery

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