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Curr Med Chem. 2019 Mar 25. doi: 10.2174/0929867326666190326113607. [Epub ahead of print]

Obesity and body composition in man and woman: associated diseases and new role of gut microbiota.

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Section of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome. Italy.
School of Specialization in Food Science, University of Rome Tor Vergata, Rome. Italy.
Health Center srl, via Sabotino 56, 87100 Cosenza. Italy.



Obesity is now recognized as a worldwide health issue and has reached epidemic proportions, affecting both developed and developing countries. The World Obesity Federation stated that "Obesity is a chronic relapsing disease process": as a result, obesity has been recognized internationally as a chronic disease. The primary cause of the metabolic syndrome and increase of the cardiovascular risk has been identified in "sick fat", a condition then defined as adiposopathy. Heart attacks, strokes, renal failures are pathologies that have mid-risk factors such as dyslipidemia, hypertension and diabetes, which in turn are caused by obesity, whose primary risk factor is represented by the diet. The aim of the present review is to consider the importance of body composition, together with a chronic inflammation and a new gut microbiota data that may turn out to be crucial elements of some target treatment of human obesity.


In this review we performed a research using PubMed database reviewing the evidence in literature of evidence information regarding the linked between obesity and body composition in develop of metabolic disease via inflammation markers and in particular the new role exerted by gut microbiota.


Several papers were evaluated searching for differences in the fat mass and disease risk. We also identified same papers dealing with differences in body composition and metabolic syndrome. Our attention it was focusing also on a new frontier of gut microbiota composition in the body weight decrease and anti-inflammatory effects.


To the saving of lean mass, for the prevention of cardiometabolic diseases, also considering the relationship with obesity, it is necessary to reduce the inflammatory state, acting on the gut-microbiota and on the intestinal permeability. To improve the health of the intestinal flora we propose a 4P medicine and treatment with: probiotics, prebiotics, postbiotics, and polyphenols.


; Body Composition; Gut Microbiota; Inflammation; Metabolic Disease; Obesity

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