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Cancer Res Treat. 2019 Feb 25. doi: 10.4143/crt.2018.704. [Epub ahead of print]

Report of the Korean Association of Lung Cancer Registry (KALC-R), 2014.

Author information

1
Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
2
Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
3
Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Korea.
4
Department of Thoracic & Cardiovascular Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
5
Center for Lung Cancer, National Cancer Center, Goyang, Korea.
6
Division of Pulmonology, Department of Internal Medicine, Chungnam National University, Daejeon, Korea.
7
Department of Medicine, Samsung Medical Center, Sungkyunkwan University, Seoul, Korea.
8
Division of Pulmonology, Department of Internal Medicine, The Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
9
Department of Cardiothoracic Surgery, Pusan National University Hospital, Busan, Korea.
10
Cancer Registration and Statistics Branch, National Cancer Center, Goyang, Korea.
11
Department of Internal Medicine, Chonnam National University Hwasun Hospital, Hwasun, Korea.
12
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

Abstract

Purpose:

The aim of this study was to investigate epidemiology, clinical characteristics and sex differences of patients with lung cancer using nationwide registry in Korea.

Materials and Methods:

The Korean Association for Lung Cancer developed a registry in cooperation with the Korean Central Cancer Registry, and surveyed about 10% of lung cancer cases. For this first survey of cases diagnosed in 2014, cases were selected through a systematic sampling method.

Results:

Total 2,621 lung cancer patients were surveyed, and the median patient age was 70 years. During the study period, adenocarcinoma was the most frequent histologic type, the proportion of female patients was 28.4%, and women had a better prognosis (median survival: not reached vs. 13 months, p<0.001) than did men for non-small cell lung cancer. The proportion of never-smokers was 36.4%, and never-smoking was more prevalent in women than in men (87.5 vs. 16.0%, p<0.001). Epidermal growth factor receptor (EGFR) mutations were found in 36.8% of stage IV adenocarcinoma patients, and higher in female compared to male patients (51.2 vs. 26.6%, p<0.001). In addition, patients with EGFR mutation showed better survival (median survival, 18 vs. 8 months; p<0.001) than patients without EGFR mutation in these patients.

Conclusion:

This is the first survey to gather unbiased nationwide lung cancer statistics in Korea. More than one third of lung cancer patients had no smoking history. Female had a high proportion of non-smoker, more adenocarcinoma with EGFR mutation and generally better prognosis than male.

KEYWORDS:

Epidemiology; Epidermal growth factor receptor; Korea; Lung neoplasms; Never-smokers

PMID:
30913875
DOI:
10.4143/crt.2018.704
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