Format

Send to

Choose Destination
Commun Biol. 2019 Mar 15;2:103. doi: 10.1038/s42003-019-0318-5. eCollection 2019.

Bridging human chaperonopathies and microbial chaperonins.

Author information

1
1Department of Microbiology and Immunology, School of Medicine, University of Maryland at Baltimore-Institute of Marine and Environmental Technology (IMET), Columbus Center, Baltimore, MD USA.
2
2Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Koganei, Tokyo Japan.
3
3Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, Koganei, Tokyo Japan.
4
4Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy.
5
Institute for Bioscience and Biotechnology Research (IBBR), Rockville, MD USA.

Abstract

Chaperonins are molecular chaperones that play critical physiological roles, but they can be pathogenic. Malfunctional chaperonins cause chaperonopathies of great interest within various medical specialties. Although the clinical-genetic aspects of many chaperonopathies are known, the molecular mechanisms causing chaperonin failure and tissue lesions are poorly understood. Progress is necessary to improve treatment, and experimental models that mimic the human situation provide a promising solution. We present two models: one prokaryotic (the archaeon Pyrococcus furiosus) with eukaryotic-like chaperonins and one eukaryotic (Chaetomium thermophilum), both convenient for isolation-study of chaperonins, and report illustrative results pertaining to a pathogenic mutation of CCT5.

Conflict of interest statement

The authors declare no competing interests.

Publication type

Publication type

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center