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J Res Pharm Pract. 2019 Jan-Mar;8(1):7-12. doi: 10.4103/jrpp.JRPP_18_55.

Early Effects of Atorvastatin on Vitamin D and Parathyroid Hormone Serum Levels Following Acute Myocardial Infarction.

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Department of Clinical Pharmacy, Zabol University of Medical Sciences, Zabol, Iran.
Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran.
Department of Clinical Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Cardiology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.



High Vitamin D serum level after acute myocardial infarction (aMI) has shown to increase cardiac reconstruction by increasing cell survival and enhancing angiogenesis. Atorvastatin has a well-defined role in both primary and secondary prevention of cardiovascular diseases. It is suggested that this effect may partly be attributable to raising 25-hydroxyvitamin D concentrations. The aim of this study was to evaluate atorvastatin effects on Vitamin D and parathyroid hormone (PTH) levels early after aMI.


All patients admitted with aMI in Imam Reza Hospital, Mashhad, Iran, from July 2014 to March 2015, were included in this pre- and postintervention study. Serum levels of Vitamin D and PTH were measured on admission and the 3rd day after administration of atorvastatin 80 mg/day.


A total of 69 post-aMI patients (47 males and 22 females) were enrolled in this study. Serum levels of Vitamin D and PTH were significantly higher (23.52 ng/ml and 46.04 pg/ml, respectively) after 72 h of atorvastatin therapy compared to the baseline (19.66 ng/ml and 31.19 pg/ml, respectively) (P = 0.004 and 0.002, respectively).


The early post-aMI beneficial effects of atorvastatin can be attributed to increased serum Vitamin D level; however, atorvastatin cannot significantly decrease serum PTH level after aMI. Further studies are needed to elucidate the clinical effect of atorvastatin.


Acute myocardial infarction; Atorvastatin; Vitamin D; parathyroid hormone

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