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J Res Pharm Pract. 2019 Jan-Mar;8(1):7-12. doi: 10.4103/jrpp.JRPP_18_55.

Early Effects of Atorvastatin on Vitamin D and Parathyroid Hormone Serum Levels Following Acute Myocardial Infarction.

Author information

1
Department of Clinical Pharmacy, Zabol University of Medical Sciences, Zabol, Iran.
2
Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran.
3
Department of Clinical Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
4
Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran.
5
Department of Cardiology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
6
Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Objective:

High Vitamin D serum level after acute myocardial infarction (aMI) has shown to increase cardiac reconstruction by increasing cell survival and enhancing angiogenesis. Atorvastatin has a well-defined role in both primary and secondary prevention of cardiovascular diseases. It is suggested that this effect may partly be attributable to raising 25-hydroxyvitamin D concentrations. The aim of this study was to evaluate atorvastatin effects on Vitamin D and parathyroid hormone (PTH) levels early after aMI.

Methods:

All patients admitted with aMI in Imam Reza Hospital, Mashhad, Iran, from July 2014 to March 2015, were included in this pre- and postintervention study. Serum levels of Vitamin D and PTH were measured on admission and the 3rd day after administration of atorvastatin 80 mg/day.

Findings:

A total of 69 post-aMI patients (47 males and 22 females) were enrolled in this study. Serum levels of Vitamin D and PTH were significantly higher (23.52 ng/ml and 46.04 pg/ml, respectively) after 72 h of atorvastatin therapy compared to the baseline (19.66 ng/ml and 31.19 pg/ml, respectively) (P = 0.004 and 0.002, respectively).

Conclusion:

The early post-aMI beneficial effects of atorvastatin can be attributed to increased serum Vitamin D level; however, atorvastatin cannot significantly decrease serum PTH level after aMI. Further studies are needed to elucidate the clinical effect of atorvastatin.

KEYWORDS:

Acute myocardial infarction; Atorvastatin; Vitamin D; parathyroid hormone

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