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Nat Med. 2019 May;25(5):734-737. doi: 10.1038/s41591-019-0403-9. Epub 2019 Mar 25.

Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions.

Author information

1
KG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.
2
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
3
Department of Immunology, University of Oslo, Oslo, Norway.
4
Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
5
Liver Unit, Hospital Clínic Barcelona, University of Barcelona, IDIBAPS, Barcelona, Spain.
6
Department of Informatics, University of Oslo, Oslo, Norway.
7
Department of Rheumatology, Dermatology and Infectious Diseases, Oslo University Hospital, Oslo, Norway.
8
Epidemiology, Health Research and Policy, Stanford School of Medicine, Stanford, CA, USA.
9
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
10
Department of Gastroenterology, Oslo University Hospital, Oslo, Norway.
11
KG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway. l.m.sollid@medisin.uio.no.
12
Institute of Clinical Medicine, University of Oslo, Oslo, Norway. l.m.sollid@medisin.uio.no.
13
Department of Immunology, University of Oslo, Oslo, Norway. l.m.sollid@medisin.uio.no.
14
Department of Immunology, Oslo University Hospital, Oslo, Norway. l.m.sollid@medisin.uio.no.
15
Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA. mmdavis@stanford.edu.
16
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA. mmdavis@stanford.edu.
17
The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA. mmdavis@stanford.edu.

Abstract

Combining HLA-DQ-gluten tetramers with mass cytometry and RNA sequencing analysis, we find that gluten-specific CD4+ T cells in the blood and intestines of patients with celiac disease display a surprisingly rare phenotype. Cells with this phenotype are also elevated in patients with systemic sclerosis and systemic lupus erythematosus, suggesting a way to characterize CD4+ T cells specific for disease-driving antigens in multiple autoimmune conditions.

PMID:
30911136
PMCID:
PMC6647859
DOI:
10.1038/s41591-019-0403-9
[Indexed for MEDLINE]
Free PMC Article

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