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Pediatr Res. 2019 Aug;86(2):261-268. doi: 10.1038/s41390-019-0379-7. Epub 2019 Mar 25.

Comparison of fetal growth by maternal prenatal acetaminophen use.

Author information

1
Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA. melissa.smarr@emory.edu.
2
Department of Environmental Health, Rollins School of public Health, Emory University, Atlanta, GA, USA. melissa.smarr@emory.edu.
3
School of Mathematical and Statistical Sciences, Clemson University, Clemson, SC, USA.
4
The Prospective Group, Arlington, VA, USA.
5
Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
6
College of Health and Human Services, George Mason University, Fairfax, VA, USA.

Abstract

BACKGROUND:

Equivocal findings exist regarding prenatal acetaminophen use and various adverse neonatal and childhood health outcomes, though with no data on fetal growth. We evaluated whether fetal growth differed by maternal acetaminophen use.

METHODS:

Racially diverse, healthy women with low-risk antenatal profiles from 12 US clinical centers were enrolled in a prospective cohort study and followed until delivery. Ultrasound measurements of fetal parameters and self-reported prenatal acetaminophen use were collected at enrollment and up to five follow-up visits. Prenatal acetaminophen use was dichotomized as none or any.

RESULTS:

Among 2291 women, 932 (41%) reported the use of acetaminophen medications during the current pregnancy. Estimated growth curves of fetal parameters did not differ between women reporting use of any medication containing acetaminophen and women with no reported use of the same.

CONCLUSION:

Among healthy mothers with low-risk pregnancies, maternal acetaminophen use was not associated with alterations in fetal growth.

PMID:
30911064
PMCID:
PMC6658344
[Available on 2019-09-25]
DOI:
10.1038/s41390-019-0379-7

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