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Biosci Rep. 2019 Apr 30;39(4). pii: BSR20190251. doi: 10.1042/BSR20190251. Print 2019 Apr 30.

LncRNA CASC11 promotes cancer cell proliferation in hepatocellular carcinoma by inhibiting miRNA-188-5p.

Author information

1
Department of General Surgery, Affiliated Zhongshan Hospital of Dalian University, Dalian City, Liaoning Province 116001, PR China.
2
Department of General Surgery, Affiliated Zhongshan Hospital of Dalian University, Dalian City, Liaoning Province 116001, PR China ewc5268@163.com zd86895@163.com.

Abstract

It is known that lncRNA CASC11 promotes the development of gastric cancer. Our study was carried out to investigate the possible involvement of ncRNA CASC11 in hepatocellular carcinoma (HCC). In the present study, we found that CASC11 was up-regulated, while miR-188-5p was down-regulated in tumor tissues of HCC patients. CASC11 and miR-188-5p were not affected by HBV and HCV infections. Follow-up study showed that high levels of CASC11 were significantly correlated with poor survival. Expression levels of CASC11 and miR-188-5p were inversely correlated in tumor tissues. CASC11 overexpression mediated the down-regulation of miR-188-5p, while miR-188-5p overexpression failed to affect CASC11 expression. CASC11 overexpression led to promoted, while miR-188-5p overexpression led to inhibited proliferation of cells of HCC cell lines. CASC11 overexpression showed no significant effects on cancer cell migration and invasion. In addition, miR-188-5p overexpression attenuated the enhancing effects of CASC11 overexpression on cancer cell proliferation. Therefore, LncRNA CASC11 promoted cancer cell proliferation in HCC possibly by inhibiting miR-188-5p.

KEYWORDS:

hepatocellular carcinoma; lncRNA CASC11; miR-188-5p; survival

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