Format

Send to

Choose Destination
Molecules. 2019 Mar 22;24(6). pii: E1139. doi: 10.3390/molecules24061139.

Improvement of Colonic Immune Function with Soy Isoflavones in High-Fat Diet-Induced Obese Rats.

Luo Q1,2, Cheng D3,4, Huang C5,6, Li Y7,8, Lao C9,10, Xia Y11,12, Liu W13,14, Gong X15, Hu D16, Li B17, He X18, Chen Z19,20.

Author information

1
Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. lqhbiology@163.com.
2
Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. lqhbiology@163.com.
3
Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. chengdongjing@126.com.
4
Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. chengdongjing@126.com.
5
Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. huangchao@sicau.edu.cn.
6
Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. huangchao@sicau.edu.cn.
7
Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. yifanli0817@163.com.
8
Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. yifanli0817@163.com.
9
Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. laocj163@163.com.
10
Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. laocj163@163.com.
11
Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. xiayu113bvs@163.com.
12
Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. xiayu113bvs@163.com.
13
Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. liuwt1986@126.com.
14
Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. liuwt1986@126.com.
15
College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. gongxx0601@163.com.
16
College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. hudlo226@163.com.
17
College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. LinBin344@163.com.
18
College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. HXzm159@163.com.
19
Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. chzhli75@163.com.
20
Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. chzhli75@163.com.

Abstract

Background: The damage to intestinal barrier function plays an important role in the development of obesity and associated diseases. Soy isoflavones are effective natural active components for controlling obesity and reducing the level of blood lipid. Here, we explored whether these effects of soy isoflavones were associated with the intestinal barrier function. Methods and Results: The obese rat models were established by high fat diet feeding. Then, those obese rats were supplemented with soy isoflavones at different doses for 4 weeks. Our results showed that obesity induced the expressions of pro-inflammatory cytokines, decreased the anti-inflammatory cytokine (IL-10) expression, elevated intestinal permeability, altered gut microbiota and exacerbated oxidative damages in colon. The administration of soy isoflavones reversed these changes in obese rats, presenting as the improvement of intestinal immune function and permeability, attenuation of oxidative damage, increase in the fraction of beneficial bacteria producing short-chain fatty acids and short-chain fatty acid production, and reduction in harmful bacteria. Furthermore, soy isoflavones blocked the expressions of TLR4 and NF-κB in the colons of the obese rats. Conclusions: Soy isoflavones could improve obesity through the attenuation of intestinal oxidative stress, recovery of immune and mucosal barrier, as well as re-balance of intestinal gut microbiota.

KEYWORDS:

colon; intestinal barrier function; obesity; soy isoflavones

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center