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Cancer Biomark. 2019;24(4):449-459. doi: 10.3233/CBM-182197.

SIRT5 downregulation is associated with poor prognosis in glioblastoma.

Chen X1,2, Xu Z3, Zeng S1,2, Wang X1,2, Liu W1,2, Qian L1,2, Wei J1,2, Yang X1,2, Shen Q1,2, Gong Z1,2, Yan Y1,2.

Author information

1
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
2
Institute for Rational and Safe Medication Practices, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
3
Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

Abstract

OBJECTIVE:

Sirtuins (SIRT) are NAD+-dependent protein deacetylases that are involved in the regulation of cancer-associated pathways. However, the biological role of these deacetylases remains elusive in glioblastoma (GBM). Here, we evaluated the effects of 7 sirtuins regarding their occurrence and prognostic value for GBM.

METHODS:

In this research, the effects of SIRT5 on the occurrence and prognosis of GBM were evaluated using integrative bioinformatics analyses.

RESULTS:

Based on comprehensive analyses of data obtained from web-based bioinformatics platforms, the data demonstrate that only SIRT5 expression is statistically decreased in GBM tissues. The clinical relevance analysis shows that downregulation of SIRT5 is significantly correlated with a shorter survival time. Moreover, the expression levels of SIRT5 were confirmed to be negatively associated with DNA methylation status. In addition, a protein-protein interaction network was constructed to determine the relationship of genes coexpressed with SIRT5. Functional enrichment analysis revealed that SIRT5 was potentially involved in epithelial-mesenchymal transition and in regulating cell communications.

CONCLUSIONS:

Collectively, our results indicate that SIRT5 acts as a potential suppresser during tumorigenesis, and suggest that SIRT5 may be a promising prognostic biomarker of GBM.

KEYWORDS:

DNA methylation; Glioblastoma; SIRT5; overall survival; prognosis

PMID:
30909186
DOI:
10.3233/CBM-182197

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