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Gynecol Oncol. 2019 Mar 21. pii: S0090-8258(19)30436-6. doi: 10.1016/j.ygyno.2019.03.243. [Epub ahead of print]

Trends and characteristics of epithelial ovarian cancer in Japan between 2002 and 2015: A JSGO-JSOG joint study.

Author information

1
Department of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa, Japan.
2
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
3
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
4
Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.
5
Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Tokyo, Japan.
6
Department of Obstetrics and Gynecology, Tokyo Women's Medical University, Tokyo, Japan.
7
Department of Obstetrics and Gynecology, Otaru General Hospital, Sapporo, Japan.
8
Department of Obstetrics and Gynecology, Yamagata University, Yamagata, Japan.
9
Department of Obstetrics and Gynecology, Niigata University School of Medicine, Niigata, Japan.
10
Department of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: mmikami@is.icc.u-tokai.ac.jp.

Abstract

OBJECTIVE:

To examine the trends of epithelial ovarian cancer histologic subtypes in Japan.

METHODS:

A nationwide retrospective registry study was performed between 2002 and 2015 (Japan cohort, n = 48,640). Trends were also examined in The Surveillance, Epidemiology, and End Results Program (US cohort, n = 49,936). Time-specific proportional changes of four major histological subtypes (serous, clear cell, endometrioid, and mucinous) were examined.

RESULTS:

The Japan cohort had more stage I disease (44.1% versus 24.9%) and less stage IV disease (10.0% versus 23.1%) than the US cohort (P < 0.001). The Japan cohort had more non-serous histology, particularly clear cell carcinoma (26.9% versus 8.4%), than the US cohort (P < 0.001). In the Japan cohort, proportion of clear cell carcinoma increased significantly from 23.4% to 29.1% between 2002 and 2010 (P < 0.001). Among stage I disease, clear cell carcinoma increased significantly in the Japan cohort from 32.9% to 40.3% between 2002 and 2015 (P < 0.001), whereas mucinous carcinoma increased significantly in the US cohort from 15.0% to 24.8% (P = 0.01). In 2015, clear cell carcinoma was most common among women aged <50 years from the Japan cohort (30.2%) versus serous carcinoma in the US cohort (50.8%). In the Japan cohort, the peak age was 75 years for serous, 57 for clear cell, and 45 for endometrioid carcinoma (P < 0.001). Mucinous carcinoma decreased until 43 years and increased again after age 73 years (P < 0.001).

CONCLUSION:

Characteristics of epithelial ovarian cancer in Japan are largely different compared to the US. In Japan, clear cell carcinoma has increased significantly in recent years to account for nearly 30% of epithelial ovarian cancer.

KEYWORDS:

Clear cell; Histology; Ovarian cancer; Stage; Survival; Trends

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