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Tumori. 2019 Jun;105(3):216-224. doi: 10.1177/0300891619839292. Epub 2019 Mar 25.

Survival benefit of first-generation epidermal growth factor receptor-tyrosine kinase inhibitors in female with advanced lung cancer.

Author information

1
1 Department of Pulmonology and Critical Care Medicine, Division of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
2
2 Department of Oncology, Division of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
3
3 Current address: Department of Hematology-Oncology, Division of Internal Medicine, KonKuk University Medical Center, Seoul, Korea.
4
4 Current address: Department of Pulmonary, Allergy, and Critical Care Medicine, Division of Internal Medicine, Hallym University College of Medicine, Dongtan Sacred Heart Hospital, Dongtan, Korea.
5
5 Department of Biomedical Systems Informatics Yonsei University College of Medicine, Seoul, Korea.

Abstract

BACKGROUND:

This study aimed to estimate therapeutic effects of first-generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) in real-world practice, by analyzing survival outcomes in an unselected, Korean female population with advanced lung cancer based on the National Health Insurance Service database.

METHODS:

We identified women with newly diagnosed advanced lung cancer from January 2004 to December 2013. For progression-free survival (PFS) and overall survival (OS) analyses, patients were defined into the following subgroups: group A, treated with first-generation EGFR-TKI ⩾6 months; group B, treated with EGFR-TKIs <6 months but at least >1 month; and group C, treated with cytotoxic chemotherapy as follows: monotherapy or combination therapy with gemcitabine or pemetrexed; or monotherapy with docetaxel, paclitaxel, or vinorelbine.

RESULTS:

Among 11,045 enrolled patients, 6170 (55.8%) were treated with first-generation EGFR-TKIs for at least 1 month. The median OS for patients treated with EGFR-TKIs was significantly longer than that of EGFR-TKI-naive patients (19.1 months [95% confidence interval (CI) 18.5-19.7] vs 9.5 months [95% CI 9.1-9.8], P<0.001). In subgroup analysis, group A had a significantly longer median OS compared with group B (30.3 months [95% CI 29.5-31.2] vs 12.3 months [95% CI 11.9-12.7], P<0.001). The median PFS of group A was significantly longer than that of group B (15.8 vs 3.7 months, P<0.001).

CONCLUSIONS:

Our analysis demonstrates that EGFR-TKIs confer significant PFS and OS benefits in the real-world practice for Korean female with advanced lung cancer.

KEYWORDS:

Advanced lung cancer; EGFR-TKI; Korea; big data; female

PMID:
30905312
DOI:
10.1177/0300891619839292
[Indexed for MEDLINE]

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