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Abdom Radiol (NY). 2019 Jul;44(7):2403-2408. doi: 10.1007/s00261-019-01990-9.

Assessment of liver T1 mapping in fontan patients and its correlation with magnetic resonance elastography-derived liver stiffness.

Author information

1
Division of Pediatric Cardiology, University of Kentucky, Lexington, KY, 40506, USA.
2
Department of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA. serais@email.chop.edu.
3
Pediatric Cardiology, Cincinnati Children's Hospital, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.
4
Department of Cardiology, The Christ Hospital, 2123 Auburn Ave, Cincinnati, OH, 45219, USA.
5
Department of Radiology, Cincinnati Children's Hospital, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.
6
Pediatric Cardiology, Children's Healthcare of Atlanta, 1405 Clifton Rd. NE, Atlanta, GA, 30322, USA.

Abstract

OBJECTIVES:

To explore the utility of liver T1 mapping in Fontan patients and its correlation to magnetic resonance elastography (MRE)-derived liver stiffness.

BACKGROUND AND AIMS:

Liver disease is a major long-term extra cardiac complication in the Fontan population. MRE is frequently used to quantify liver stiffness in Fontan patients; however, it has certain limitations. Native T1 mapping by cardiac magnetic resonance (CMR) is useful in assessment of cardiac fibrosis, but its potential in evaluating liver fibrosis and its correlation to MRE-derived liver stiffness in Fontan patients have not been reported.

METHODS:

Fontan patients who underwent CMR and MRE were included. Liver Native T1, extracellular volume (ECV) and delta coefficients were measured and correlated with MRE-derived liver stiffness in all Fontan patients. Native liver T1 in Fontan patients were compared to normal controls with biventricular circulation and no known liver disease.

RESULTS:

A total of 17 Fontan patients and 7 normal controls were included in this study. Fontan patients had significantly higher liver native T1 (690 ± 41 ms vs 620 ± 35 ms; p < 0.001) as compared to controls. There was strong positive correlation between MRE derived liver stiffness and liver native T1 (r = 0.81, p < 0.001).

CONCLUSIONS:

Liver native T1 was significantly elevated in Fontan patients compared to controls and strongly correlated with MRE-derived liver stiffness. This technique may prove to be a useful noninvasive imaging biomarker for assessing liver fibrosis in the Fontan population.

KEYWORDS:

Congenital heart disease; Fontan; Liver fibrosis; Parametric mapping; Single ventricle

PMID:
30903232
DOI:
10.1007/s00261-019-01990-9

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