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Gene. 2019 Jun 20;702:114-122. doi: 10.1016/j.gene.2019.02.105. Epub 2019 Mar 19.

Expression of LRP1 and CHOP genes associated with peripheral neuropathy in type 2 diabetes mellitus: Correlations with nerve conduction studies.

Author information

1
Medical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt. Electronic address: hemat.elhorany@med.tanta.edu.eg.
2
Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
3
Internal Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
4
MD Neurology, Neuropsychiatry Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Abstract

AIM:

Diabetic peripheral neuropathy (DPN) is a frequent and debilitating complication of diabetes mellitus. The low-density lipoprotein receptor-related protein-1 (LRP-1) is a multifunctional cell surface receptor playing critical roles in lipoprotein metabolism and several cell signaling processes. C/EBP homologous protein (CHOP) is a main conduit to endoplasmic reticulum stress-induced apoptosis. We aimed to investigate LRP1 and CHOP gene expression in peripheral blood cells of type 2 diabetes mellitus (T2DM) subjects to clarify its possible relation to DPN pathogenesis.

METHOD:

The study included 20 non-complicated T2DM subjects, 20 subjects with DPN and 20 healthy controls. Quantitative real time PCR was used to study gene expression.

RESULTS:

There was a significant reduction in LRP1 mRNA expression and a significant increase in CHOP mRNA expression in subjects with DPN compared to non-complicated group and healthy controls. Both LRP1 and CHOP expression levels were inversely correlated, and both showed significant correlation with HbA1c, hyperlipidemia, hs-CRP, and different electrophysiological parameters. Receiver operating characteristics (ROC) analysis suggested that both LRP1 and CHOP mRNA expression and hs-CRP levels had great potential advantages to predict the progression of DPN.

CONCLUSION:

LRP1 and CHOP might be involved in DPN pathogenesis and progression, thus providing opportunities for early detection and treatment.

KEYWORDS:

C/EBP homologous protein; Diabetic peripheral neuropathy; Low-density lipoprotein receptor-related protein-1; Pathogenesis; T2DM

PMID:
30902789
DOI:
10.1016/j.gene.2019.02.105
[Indexed for MEDLINE]

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