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Indian J Dent Res. 2019 Jan-Feb;30(1):37-42. doi: 10.4103/ijdr.IJDR_91_16.

The antibacterial influence of nanotopographic titanium, zirconium, and aluminum nanoparticles against Staphylococcus aureus and porphyromonas gingivalis: An In vitro study.

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Department of Prosthodontics, SRM Dental College, Chennai, Tamil Nadu, India.



Nanoparticle coated implants have revolutionized the field of implantology. Peri-implantitis is one of the main for implant failure. Most implant failures are due to Streptococcus mutans, Staphylococcus aureus, Porphyromonas gingivalis, and Actinomyces concomitant.


To evaluate and compare the antibacterial effect of titanium, zirconium, aluminum nanoparticles against S. aureus and P. gingivalis at 24, 72 hrs and 1 week intervals.

Materials and Methods:

According to ISO/TR 11175:1993, the samples were prepared in disc shape with 20-mm diameter and 1-mm thickness in Grade IV titanium. The samples were decontaminated by sonicating in acetone and subsequently in water three times for 15 min. A total of eighty samples were made, then coated with nanoparticles, and divided into Group-A (control), Group-B (Ti nanoparticles coating), Group-C (Zi nanoparticles coating), and Group-D (Al nanoparticles coating). The discs were sterilized under ultraviolet radiation and placed in Mueller-Hinton agar medium for S. aureus and blood agar for P. gingivalis. The colonies were counted at 24, 72 hrs and 1 week intervals.

Statistical Analysis Used:

The values were statistically analyzed using one-way ANOVA and Tukey honestly significant difference test.


The P < 0.001 showed that statistically significant difference in colony forming unit had been found in titanium nanoparticles coated samples at 24, 72 hrs and 1 week intervals.


TiO2 nanoparticle coated titanium discs showed significant antibacterial effect.


Antimicrobial potential; nanoparticles; titanium

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