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Am J Transl Res. 2019 Feb 15;11(2):520-528. eCollection 2019.

Recent advances on the roles of epidermal growth factor receptor in psoriasis.

Author information

1
Department of Dermatology, Nanfang Hospital, Southern Medical University Guangzhou 510515, Guangdong, China.
2
Department of Dermatology, Feinberg School of Medicine, Northwestern University Chicago 60611, IL, USA.
3
Department of Radiology, Feinberg School of Medicine, Northwestern University Chicago 60611, IL, USA.

Abstract

Epidermal growth factor receptor (EGFR) is a well-characterized receptor tyrosine kinase that involved in many vital activities in cell development, such as cellular homeostasis, proliferation, division, differentiation and apoptosis. Natural activation of EGFR and the concomitant downstream signaling pathways regulation are substantial to maintain normal cellular functions. In recent studies, EGFR was demonstrated to be a fundamental modulator in the control of skin inflammatory responses. Several dermatologic diseases including psoriasis are related to the anomalous activation of EGFR signaling. It has been proved that the expression and activity of EGFR and its endogenous ligands are overexpressed in the active epidermis lesions of psoriasis. Moreover, the remarkable therapeutic improvement of chronic psoriasis in cancer patients during the treatment of EGFR inhibitors or anti-EGFR monoclonal antibodies are also recorded, suggesting that the EGFR-mediated signaling may conduct a crucial role in the pathophysiology of psoriasis.

KEYWORDS:

EGF; EGFR; keratinocytes; psoriasis

PMID:
30899359
PMCID:
PMC6413281

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