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Acta Radiol. 2019 Mar 21:284185119834689. doi: 10.1177/0284185119834689. [Epub ahead of print]

Comparison of invasive micropapillary and invasive ductal carcinoma of the breast: a matched cohort study.

Author information

1
Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

Abstract

BACKGROUND:

Invasive micropapillary carcinoma (IMPC) is a rare subtype of breast cancer and is presumed to have a poorer survival outcome than invasive ductal carcinoma (IDC). However, studies for clinical outcomes including imaging features are still scarce.

PURPOSE:

To investigate differences in clinical outcomes between IMPC and IDC and to determine prognostic factors indicating survival, including imaging features.

MATERIAL AND METHODS:

This retrospective study was approved by the institutional review board. Between 2007 and 2012, 308 women diagnosed with IMPC were matched with patients from a group of 6816 women diagnosed with IDC. Patients were matched with 17 clinicopathologic covariates using propensity score matching. Recurrence-free survival (RFS) and overall survival (OS) were compared between the IMPC and IDC groups using Kaplan-Meier estimates. Log-rank tests were performed to compare the survival curves. A Cox proportional hazard model was used to analyze the association of imaging features with survival.

RESULTS:

In total, 308 matched patient pairs were available for survival analysis. The IMPC group showed worse total RFS (hazard ratio [HR] = 1.63, P = 0.016), local RFS (HR = 2.86, P = 0.042), and distant RFS (HR = 1.85 P = 0.018), but there was no significant difference in OS (HR = 1.30, P = 0.335). A mass with calcification on mammography was an independent factor for worse RFS in the IMPC group and combined IMPC and IDC groups. IMPC subtype was a significant independent factor for worse RFS in the combined groups.

CONCLUSION:

The IMPC group showed poorer recurrence-free survival outcomes than the IDC group. A mass with calcification on mammography were associated with poor RFS.

KEYWORDS:

Invasive micropapillary carcinoma; invasive ductal carcinoma; magnetic resonance imaging; mammography; survival; ultrasound

PMID:
30897929
DOI:
10.1177/0284185119834689

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