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Zhonghua Shao Shang Za Zhi. 2019 Mar 20;35(3):221-223. doi: 10.3760/cma.j.issn.1009-2587.2019.03.011.

[Five patients with severe burns complicated by fungal infection].

[Article in Chinese; Abstract available in Chinese from the publisher]

Author information

1
Department of Burns, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China.

Abstract

in English, Chinese

From June to November 2016, 5 patients with severe burns were admitted to our unit. Broad-spectrum antibiotic and fluconazole were used on patients as earlier empirical anti-infection therapy of bacteria and fungi. Seven to twenty-one days after injury, 5 patients developed fungal infection. Antifungal agents of caspofungin, voriconazole, and amphotericin B liposomewere were used according to the results of fungal culture, and the infected wounds were also treated with repeated debridement and dressing change. Multiple autologous skin grafts were performed after infection control of wounds. With the above antifungal infection treatment for 5 to 11 days, 2 patients' condition tended to be stable, and no fungus was found in wound secretion after cultured for many times. The patients were discharged with wounds healed after 52 to 54 days' hospital stay. Due to severe burns degree and or elder age, fungal infection aggravated and expanded to the trunk in the other 3 patients, then developed into burn sepsis, resulting in patients died of multiple organ failure secondary to sepsis.

KEYWORDS:

Antifungal agents; Burns; Fungi; Infection

[Indexed for MEDLINE]

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