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J Biomater Sci Polym Ed. 2019 May;30(7):547-560. doi: 10.1080/09205063.2019.1586303. Epub 2019 Apr 7.

Mechanical properties and degradation of drug eluted bioresorbable vascular scaffolds prepared by three-dimensional printing technology.

Author information

1
a Department of Vascular Surgery , Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School , Nanjing , People's Republic of China.
2
b School of Chemistry and National and Local Joint Engineering Research Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biofunctional Materials Materials Science , Nanjing Normal University , Nanjing , People's Republic of China.
3
c Department of Vascular and Interventional Radiology , Wujin People's Hospital Affilicated to Jiangsu University , Changzhou , People's Republic of China.

Abstract

Bioresorbable vascular scaffolds are expected to replace the traditional metal stent, avoiding the long-term complications of metal stents. However, it is hard for the traditional scaffold manufacturing process to meet the requirements of individualized treatment for vascular lesions, which requires different morphologies. Here, we used a new method of scaffold manufacturing, three-dimensional printing technology, to prepare bioresorbable vascular scaffolds. The fabricated scaffold was loaded with sirolimus mixed with scaffold preparation material for slow drug release. The engineered, drug- loaded, bioresorbable vascular scaffold (BVS) was analyzed and tested in vivo. The scaffolds produced by three-dimensional printing technology exhibited good mechanical properties and in vitro degradation performance. The results also suggested that these scaffolds could maintain effective radial strength after long-term degradation and sustained release of the drug. As a new scaffold preparation method, it may provide a promising idea for developing bioresorbable vascular scaffold technology.

KEYWORDS:

Bioresorbable vascular scaffolds; degradation; drug release; mechanical property; three-dimensional printing technology

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