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Chem Commun (Camb). 2019 Apr 4;55(29):4222-4225. doi: 10.1039/c9cc00175a.

DNA tetrahedron-based nanogels for siRNA delivery and gene silencing.

Author information

1
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, People's Republic of China. chuanzhang@sjtu.edu.cn gxh0198@sjtu.edu.cn.

Abstract

DNA tetrahedra are employed as building blocks to construct a novel DNA-based nanogel for intracellular siRNA delivery. With a compact architecture that embeds functional siRNA inside, the self-assembled nanogel can efficiently enter cells and knock down the target gene expression, making them potential noncationic vectors for functional nucleic acid delivery.

PMID:
30896698
DOI:
10.1039/c9cc00175a
[Indexed for MEDLINE]

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