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Medicine (Baltimore). 2019 Mar;98(12):e14942. doi: 10.1097/MD.0000000000014942.

Association between NAT2 polymorphisms and acute leukemia risk: A meta-analysis.

Author information

1
Laboratory for molecular immunology, Institute of Basic Medicine, Shandong Academy of Medical Sciences.
2
Breast Cancer Center, Shandong Cancer Hospital Affiliated to Shandong University.
3
Gaomi Municipal Hospital, Gaomi.
4
School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences.
5
Department of peripheral vascular disease, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.

Abstract

BACKGROUND:

N-acetyl-transferase 2 (NAT2) polymorphisms have been demonstrated to be associated with acute leukemia (AL); however, the results remain controversial. The present meta-analysis was performed to provide more precise results.

METHODS:

Pubmed, Embase, Cochrane Library, China National Knowledge Infrastructure, and Wanfang databases were used to identify eligible studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between NAT2 polymorphisms and AL risk.

RESULTS:

Increased risk was found under both heterozygous (OR 1.24, 95% CI 1.02-1.51) and recessive model (OR 1.28, 95% CI 1.06-1.55) for rs1801280. The slow acetylator phenotype (OR 1.22, 95% CI 1.07-1.40) also increased AL risk. Subgroup analysis demonstrated that rs1801280 increased AL risk under the recessive model (OR 1.14, 95% CI 0.93-1.41) in Caucasian population and the co-dominant (OR 1.77, 95% CI 1.40-2.23), homozygous (OR 3.06, 95% CI 1.88-4.99), dominant (OR 2.22, 95% CI 1.56-3.17), recessive model (OR 2.06, 95% CI 1.35-3.16) in the Mixed populations. Association between rs1799929 and decreased AL risk was found in the co-dominant (OR 0.82, 95% CI 0.70-0.97), homozygous (OR 0.65, 95% CI 0.46-0.93), heterozygous (OR 0.71, 95% CI 0.51-1.00), and the recessive model (OR 0.68, 95% CI 0.49-0.94) in the Caucasian group. As for rs1799931, the same effects were found in the co-dominant (OR 0.68, 95% CI 0.49-0.94) and the dominant model (OR 0.68, 95% CI 0.48-0.97) in the mixed group.

CONCLUSION:

rs1801280 and the slow acetylator phenotype are risk factors for AL.

PMID:
30896661
DOI:
10.1097/MD.0000000000014942
[Indexed for MEDLINE]
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