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Medicine (Baltimore). 2019 Mar;98(12):e14930. doi: 10.1097/MD.0000000000014930.

Mid-arm circumference, body fat, nutritional and inflammatory biomarkers, blood glucose, dialysis adequacy influence all-cause mortality in hemodialysis patients: A prospective cohort study.

Author information

1
School of Nutrition and Health Sciences, Taipei Medical University.
2
Department of Nutrition and Health Sciences, Chinese Culture University.
3
School of Medicine, Taipei Medical University.
4
Department of Nephrology, Taipei Medical University Hospital.
5
Department of Nephrology, Taipei Medical University-Wan Fang Hospital.
6
Division of Nephrology, Department of Internal Medicine, Taipei Medical University- Shuang Ho Hospital.
7
Division of Nephrology, Cathay General Hospital.
8
Division of Nephrology, Taipei Tzu-Chi Hospital, New Taipei 231.
9
Department of Nephrology, Wei Gong Memorial Hospital, Miaoli 351.
10
Department of Nephrology, Lotung Poh-Ai Hospital, Yilan 265.
11
Research Center of Geriatric Nutrition, Taipei Medical University.
12
Nutrition Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan.

Abstract

Hemodialysis patients are at the high risk for morbidity and mortality. Evaluation and management of body composition and biochemical values are important to improve dialysis outcomes. We aimed to examine the effects of the mid-arm circumference, body fat, nutritional and inflammatory biomarkers, blood glucose, and dialysis adequacy on the mortality.A prospective cohort study was conducted on 375 patients from 7 hospital-based dialysis centers. At baseline between September 2013 and April 2017, we assessed patients' characteristics using chart review, body composition using the bioelectrical impedance analysis, and biochemical parameters using available laboratory tests. Patients were followed-up for all-cause mortality until April 2018. Kaplan-Meier Curves with Log-rank test, and Cox proportional hazards models were used to analyze the effects of assessed factors on the mortality.During the median of follow-up time of 1.4 (1.0-3.2) years, 47 (12.5%) patients died. In the multivariate analysis, mid-arm circumference (hazard ratio, HR, 0.90; 95% confidence interval, 95%CI, 0.82-0.99; P = .036), body fat mass (HR, 0.95; 95%CI, 0.91-1.00; P = .031), percent body fat (HR, 0.96; 95%CI, 0.92-0.99; P = .024), serum creatinine (HR, 0.81; 95%CI, 0.68-0.96; P = .015), and eKt/V (HR, 0.07; 95%CI, 0.01-0.33; P = .001) reduced the mortality risk. Inflammation (HR, 2.90; 95%CI, 1.59-5.27; P < .001), hyperglycemia (HR, 2.16; 95%CI, 1.06-4.40; P = .033), and low serum uric acid (HR, 2.22; 95%CI, 1.15-4.31; P = .018) increased the death risk.In hemodialysis patients, the higher values of the mid-arm circumference, body fat, serum creatinine, uric acid, and dialysis adequacy were associated with lower mortality, whereas, inflammation and hyperglycemia associated with higher mortality.

PMID:
30896655
DOI:
10.1097/MD.0000000000014930
[Indexed for MEDLINE]
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