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Environ Health. 2019 Mar 20;18(1):22. doi: 10.1186/s12940-019-0463-9.

Exposure to prenatal secondhand smoke and early neurodevelopment: Mothers and Children's Environmental Health (MOCEH) study.

Author information

1
Department of Occupational and Environmental Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
2
Department of Preventive Medicine, College of Medicine, Dankook University, Cheonan, Republic of Korea.
3
Institute of Environmental Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea.
4
Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
5
Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.
6
Department of Psychiatry, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
7
Department of Child and Adolescent Psychiatry, National Center for Mental Health, Seoul, Republic of Korea.
8
Department of Occupational and Environmental Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea. eunheeha@ewha.ac.kr.
9
Ewha Medical Research Institute, School of Medicine, Ewha Womans University, Seoul, Republic of Korea. eunheeha@ewha.ac.kr.

Abstract

BACKGROUND:

The association between exposure to secondhand smoke (SHS) during pregnancy and a child's neurodevelopment has not been established yet. We explored the association between prenatal exposure to SHS and neurodevelopment at 24 months of age considering genetic polymorphism and breastfeeding in 720 mothers and their offspring enrolled in the Korean multicenter birth cohort study (Mothers and Children Environmental Health, MOCEH).

METHODS:

We quantified urine cotinine concentrations in mothers once from 12th to 20th gestational weeks and excluded those whose urine cotinine levels exceeded 42.7 ng/ml to represent SHS exposure in early pregnancy. Mental developmental index (MDI) and psychomotor developmental index (PDI) values were measured using the Korean version of the Bayley Scales of Infant Development II (K-BSID-II) at 24 months of age. A general linear model was used to assess the relationship between maternal urinary cotinine level and neurodevelopment.

RESULTS:

MDI scores were inversely associated with cotinine [β = - 2.73; 95% confidence interval (CI): - 5.32 to - 0.15] in children whose mothers had early pregnancy urinary cotinine levels >1.90 ng/ml. No association was evident in children whose mothers had cotinine levels ≤1.90 ng/ml. This negative association was more pronounced in children whose mothers had both Glutathione S-transferases mu 1 (GSTM1) and theta 1 (GSTT1) null type [β = - 5.78; 95% CI: -10.69 to - 0.87], but not in children whose mothers had any present type of GSTM1/GSTT1 [β = - 1.64; 95% CI: -4.79 to 1.52]. The association was no longer significant when children received breast milk exclusively for up to 6 months [β = - 0.24; 95% CI: -4.69 to 4.20] compared to others [β = - 3.75; 95% CI: -7.51 to 0.00]. No significant association was found for PDI.

CONCLUSIONS:

Maternal exposure to SHS during pregnancy may result in delayed MDI in early childhood. This effect might be modified by genetic polymorphism and breastfeeding behavior.

KEYWORDS:

24 months; Breastfeeding; Genetic polymorphism; Infant neurodevelopment; Secondhand smoke; Urine cotinine

PMID:
30894196
PMCID:
PMC6425627
DOI:
10.1186/s12940-019-0463-9
[Indexed for MEDLINE]
Free PMC Article

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