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Immunity. 2019 Mar 19;50(3):547-549. doi: 10.1016/j.immuni.2019.02.019.

Exosomes Exercise Inhibition of Anti-Tumor Immunity during Chemotherapy.

Author information

1
Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA; Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
2
Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. Electronic address: rkalluri@mdanderson.org.

Abstract

Exosomes are nano-sized extracellular vesicles that contain DNA, RNA, proteins, and lipids. Exosomes likely participate in facilitating intercellular communication and tumor growth. In this issue of Immunity, Zhang et al. (2019) report on the metabolic activity of B cell-derived exosomes in facilitating the suppression of cytotoxic T cells.

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