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Cien Saude Colet. 2019 Mar;24(3):827-838. doi: 10.1590/1413-81232018243.07112017.

Efect of vitamin A suplementation: a systematic review.

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Ciência da Nutrição, Departamento de Nutrição e Saúde, Universidade Federal de Viçosa. Ed. Centro de Ciências Biológicas II Centro Universitário. 36570-000 Viçosa MG Brasil.
Estratégia Saúde da Família Santa Clara - Coelhas/Sol Nascente. Viçosa MG Brasil.
Curso de Nutrição, Faculdade de Medicina, Universidade Federal de Uberlândia. Uberlândia MG Brasil.


To evaluate the effect of vitamin A supplementation in postpartum infants and women on serum retinol levels and breast milk. The databases Medline, PubMed, Lilacs and SciELO were consulted. The descriptors used were vitamin A, dietary supplement, child, postpartum period, infant and nutrition programs policies. Search found 7432 articles. After elimination of duplicity and application of eligibility criteria, 8 studies remained. All evaluated the effect of vitamin A supplementation on immediate postpartum, five studies used retinyl palmitate supplementation, one with retinyl palmitate and two did not specify the form of supplementation. Six studies evaluated colostrum and two included supplementation of children. It was found that supplementation in the puerperium increases the concentrations of serum retinol and breast milk, however, this result was in the short term and was relevant when the previous concentrations of the mother were low. When maternal serum concentrations are adequate, the retinol content in milk does not change, with little relevance for children. Further studies should be performed to evaluate the effect of megadoses supplementation on serum concentrations of children.

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