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Animal Model Exp Med. 2018 Apr 19;1(1):29-35. doi: 10.1002/ame2.12008. eCollection 2018 Mar.

Overview of the reporter genes and reporter mouse models.

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Key Laboratory of Medical Molecular Virology Shanghai Public Health Clinical Center Ministry of Education and Health Fudan University Shanghai China.
School of Agriculture and Biology Shanghai Jiao Tong University Shanghai China.


Reporter genes are widely applied in biotechnology and biomedical research owning to their easy observation and lack of toxicity. Taking advantage of the reporter genes in conjunction with imaging technologies, a large number of reporter mouse models have been generated. Reporter mouse models provide systems that enable the studies of live cell imaging, cell lineage tracing, immunological research and cancers etc. in vivo. In this review, we describe the types of different reporter genes and reporter mouse models including, random reporter strains, Cre reporter strains and ROSA26 reporter strains. Collectively, these reporter mouse models have broadened scientific inquires and provided potential strategies for generation of novel reporter animal models with enhanced capabilities.


Cre reporter strains; ROSA26 reporter strains; random reporter strains; reporter genes

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