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Parkinsonism Relat Disord. 2019 Jul;64:60-65. doi: 10.1016/j.parkreldis.2019.03.007. Epub 2019 Mar 15.

Clinical utility of SUDOSCAN in predicting autonomic neuropathy in patients with Parkinson's disease.

Author information

1
Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, Guangdong Province, PR China. Electronic address: xuxf5@mail.sysu.edu.cn.
2
Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, Guangdong Province, PR China. Electronic address: 285895614@qq.com.
3
Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, Guangdong Province, PR China. Electronic address: dongqing2009tracy@163.com.
4
Department of Neurosurgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, Guangdong Province, PR China. Electronic address: brainqin@163.com.
5
Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, Guangdong Province, PR China. Electronic address: wendy_lij81@163.com.
6
Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, Guangdong Province, PR China. Electronic address: sister_555@163.com.
7
Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, Guangdong Province, PR China. Electronic address: ttvirus@163.com.
8
Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, Guangdong Province, PR China. Electronic address: lingf0313@qq.com.
9
Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, Guangdong Province, PR China. Electronic address: pfh93@163.com.
10
Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, Guangdong Province, PR China. Electronic address: lzq1828@aliyun.com.
11
Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, Guangdong Province, PR China. Electronic address: qiuwei120@vip.163.com.

Abstract

INTRODUCTION:

Autonomic neuropathy is common in Parkinson's disease (PD). We evaluated whether SUDOSCAN, a novel electrophysiological device that provides a simple and quantitative assessment of sudomotor function, was able to detect PD-related autonomic neuropathy. We also used the device to examine potential risk factors for PD-related autonomic neuropathy.

METHODS:

Forty-three hospitalized patients in the later stages of PD underwent assessments including a clinical history, the Unified Parkinson's Disease Rating Scale (UPDRS), the Scale for Outcomes in Parkinson's disease for Autonomic Symptoms (SCOPA-AUT), and measurement of homocysteine (HCY) and vitamin B12 levels. Sudomotor function was assessed by measuring electrochemical skin conductance (ESC) using SUDOSCAN. Forty-two healthy participants served as controls.

RESULTS:

ESC of the limbs, and especially the hands, was significantly lower in PD patients than in controls and was significantly correlated with SCOPA-AUT results. ESC was strongly negatively correlated with PD duration. The results also indicated that levodopa exposure and a higher HCY level may be risk factors for PD-related autonomic neuropathy.

CONCLUSIONS:

SUDOSCAN was able to effectively identify autonomic neuropathy in PD patients. ESC was decreased in PD patients and was correlated with PD-related autonomic symptoms. These findings suggest that SUDOSCAN could be a promising new method for assessing PD-related autonomic neuropathy.

KEYWORDS:

Autonomic neuropathy; Homocysteine; Levodopa; Parkinson's disease; Sudomotor

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