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Diagn Microbiol Infect Dis. 2019 Aug;94(4):391-394. doi: 10.1016/j.diagmicrobio.2019.02.007. Epub 2019 Feb 10.

Association of systemic antimicrobials with the expression of beta-lactamases in bacteria cultured from urological patients.

Author information

1
Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
2
Department of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
3
Division of Pharmacy, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
4
Department of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: Joel.Mortensen@cchmc.org.

Abstract

BACKGROUND:

Patients with abnormalities of the genitourinary tract are at high risk for infections with antimicrobial-resistant pathogens.

METHODS:

All urine cultures ordered by members of the Division of Urology from four quarterly one-week periods were included. All gram-negative bacilli isolated were analyzed using the Check-Points Check-MDR CT103XL assay to identify the presence of genes associated with resistance to beta-lactam antibiotics. Association between the days of antibiotics and the presence of an ESBL-producing organism was determined.

RESULTS:

One hundred eleven positive cultures were included in this analysis, of which 5 (4.5%) contained ESBL-producing species. Days of systemic antibiotics within 30 days of urine culture was associated with an increased risk of isolating an ESBL-producing pathogen.

CONCLUSION:

The overall prevalence of ESBL-producing organisms is low in this cohort. The number of days of systemic antibiotics within 30 days of a urine culture was significantly associated with increased risk of isolating an ESBL-producing organism.

KEYWORDS:

Antibiotic resistance; Urinary tract infections; beta-Lactamase

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