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Chin Med J (Engl). 2019 Mar 16. doi: 10.1097/CM9.0000000000000203. [Epub ahead of print]

Identification of new fusion genes and clinical significance in endometrial cancer.

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1
Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China.

Abstract

BACKGROUND:

Fusion genes may be play an important role in tumorigenesis, prognosis, and drug-resistance, while the study of fusion genes in endometrial cancer(EC) is rare. This study aimed to identify the new fusion genes and explore the clinical significance in EC.

METHODS:

A total of 28 patients diagnosed EC were enrolled in this study. RNA sequencing was used to obtain entire genomes and transcriptomes. STAR comparison and STAR-fusion predict were applied to predict the fusion genes. Chi-square test and Student-t test were used to verify the clinical significance by SPSS 13.0 software.

RESULTS:

The new fusion genes were found and the number of fusion genes varies from 3 to 110 in all endometrial cancer patients. The type of fusion genes varies including mRNA-mRNA, LncRNA-LncRNA, LncRNA-mRNA. There were 6 fusion genes that have high fusion rate including RP11-123O10.4--GRIP1, RP11-444D3.1--SOX5, RP11-680G10.1--GSE1, NRIP1--AF127936.7, RP11-96H19.1--RP11-446N19.1, and DPH7--PTP4A3. Further studies have shown that these fusion genes were related to stage, grade and recurrence, in which NRIP1--AF127936.7 and DPH7--PTP4A3 only be found in stage III endometrial cancer patients. DPH7--PTP4A3 be found in grade 2, 3 and recurrence endometrial cancer.

CONCLUSION:

Fusion genes act as an essential role in endometrial cancer. There were six over-expression and high fusion rate genes. NRIP1--AF127936.7 and DPH7--PTP4A3 might related to stage and DPH7--PTP4A3 are related to grade and recurrence.Thisis an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0.

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