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Aging (Albany NY). 2019 Mar 19;11(6):1686-1694. doi: 10.18632/aging.101862.

Trends in the incidence of recurrent stroke at 5 years after the first-ever stroke in rural China: a population-based stroke surveillance from 1992 to 2017.

Zhao W1,2, Wu J1,2, Liu J3,4,5, Wu Y3,4,5, Ni J3,4,5, Gu H6, Tu J3,4,5, Wang J3,4,5, An Z1,2, Ning X3,4,5.

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Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300350, China.
Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Disease, Tianjin 300350, China.
Department of Neurology, Tianjin Medical University General Hospital, Tianjin 300052, China.
Laboratory of Epidemiology, Tianjin Neurological Institute, Tianjin 300052, China.
Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin 300052, China.
Department of Neurology, Tianjin Haibin People's Hospital, Tianjin 300280, China.


Recent data on the incidence and trends for recurrent strokes in China are scarce. We assessed the temporal trends in recurrent stroke incidence using in rural China. The age-standardized incidences of recurrent stroke, within 5 years of the incident stroke event, were estimated for 3 time periods: 1992-1998, 1999-2005, and 2006-2012. Among the 768 documented incident stroke cases, 26.3% of the patients experienced recurrent stroke within 5 years. The overall age-adjusted recurrent stroke incidence was 43.93 per 100,000 person-years (1992-2012). During the 2006-2012 period, the recurrent stroke incidence per 100,000 person-years was 107.79 in men, and 557.76 in individuals ≥65 years old. There were significant upward tendencies observed in this population across sex, age, or type of stroke (except for among individuals ≥65 years old with incident intracerebral hemorrhages). Compared with the recurrent stroke incidence observed in the 1992-1998 period, that observed during the 2006-2012 period was more than 3-fold higher; the greatest increase (6.8-fold) was observed in women. These findings suggest an urgent need to improve risk factor management and implement appropriate medical resources to contain this upward trend in recurrent stroke incidence and reduce the overall stroke burden in China.


epidemiology; recurrence; stroke; trend

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