Format

Send to

Choose Destination
Acta Gastroenterol Belg. 2019 Jan-Mar;82(1):11-18.

Surgical management and outcomes of duodenal gastrointestinal stromal tumors.

Author information

1
Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
2
Zhejiang University School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
3
The Fourth Clinical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Abstract

BACKGROUND AND STUDY AIMS:

This retrospective study purports to examine these characteristics and compare the surgical procedures available and appropriate for the treatment of patients affected by duodenal GISTs.

PATIENTS AND METHODS:

A retrospective examination of reports and studies carried out between May 2012 and March 2017, and covering patients with primary GISTs of the duodenum was performed using modules from the SPSS package. Comparisons of treatment effects resulting from the administration of two differential methods of surgical treatment namely pancreaticoduodenectomy (PD), and limited resection (LR), were effected on the reports of the GIST patients thus selected.

RESULTS:

Out of these 62 patients who had undergone resection of duodenal GISTs, 47 (76%) had limited resection (LR) and 15 (24%) underwent pancreaticoduodenectomy (PD). In Multivariate analyses, tumor size was an independent predictive factor for recurrence (p=0.008). ASA, tumor size, and PD were independent and significant prognostic factors on OS (p=0.021, p=0.024, and p=0.030, respectively). In the very low and low risk group, and high-risk group, there were no significant differences in the RFS (recurrence-free survival) and OS (overall survival) between the LR and PD groups.

CONCLUSIONS:

When technically feasible, LR should be given due consideration as a reliable and curative option for duodenal GISTs achieving satisfactory RFS and OS.

KEYWORDS:

duodenal tumors; gastrointestinal stromal tumors (GISTs); limited resection (LR); pancreaticoduodenectomy (PD); prognosis

PMID:
30888748

Conflict of interest statement

The authors declare that they have no conflict of interest

Supplemental Content

Loading ...
Support Center