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DNA Cell Biol. 2019 Mar 19. doi: 10.1089/dna.2018.4555. [Epub ahead of print]

Lack of Association Between CTLA-4 Genetic Polymorphisms and Noncardiac Gastric Cancer in a Chinese Population.

Liu J1,2, Tang W3, Lin W1,2, Wang Y4, Chen Y5, Wang J1,2, Liu M1,2, Xu W6, Lin J1,2, Zhang L1,2,5,7.

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1 First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
2 Fujian Key Laboratory of Individualized Active Immunotherapy and Key Laboratory of Radiation Biology of Fujian Province Universities, Fuzhou, China.
3 Department of Thoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China.
4 Department of Cardiology, The People's Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong, China.
5 Department of Medical Oncology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, China.
6 Department of Medical Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.
7 Department of Radiation Oncology, University of Florida, Gainesville, Florida.


Cytotoxic T lymphocyte antigen 4 (CTLA-4) is a key negative immunoregulatory molecule with characteristics of gene polymorphisms. Genetically predisposed CTLA-4 alteration in humans was associated with gastric cancer (GC) development. To explore the association of CTLA-4 polymorphism with susceptibility of noncardiac GC (NCGC), 490 NCGC patients and 1476 control individuals were studied. Four CTLA-4 polymorphisms were genotyped with SNPscan genotyping assays and the haplotypes were constructed with SHESIS software. Frequencies of the CTLA-4 haplotypes were estimated using an expectation-maximization algorithm. The CTLA-4 polymorphism genotype distribution and allele frequencies were not significantly different between the NCGC patients and the control subjects. The CTLA-4 haplotypes did not exhibit a significantly increased risk for NCGC patients. Adjusting status of age, sex, smoking status, alcohol use, and body mass index could not moderate any of the relationships. Data suggested that CTLA-4 polymorphisms (rs3087243, rs16840252, rs733618, and rs231775) were not significantly associated with the risk of NCGC in this Chinese population studied.


CTLA-4; Chinese population; SNPs; gastric cancer; noncardiac gastric cancer; polymorphisms


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