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Diabet Med. 2019 Jul;36(7):888-897. doi: 10.1111/dme.13948. Epub 2019 Apr 7.

Associations of physical activity levels and screen time with oral glucose tolerance test profiles in Singaporean women of reproductive age actively trying to conceive: the S-PRESTO study.

Author information

1
Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore.
2
Inserm, Centre for Research in Epidemiology and Statistics, Research Team on Early Life Origins of Health, Villejuif, France.
3
Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.
4
Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore.
5
Duke-NUS Medical School, National University of Singapore, Singapore.
6
Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
7
Khoo Teck Puat- National University Children's Medical Institute, National University Health System, Singapore.
8
Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
9
NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
10
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.
11
Clinical Nutrition Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, Singapore.
12
Department of Endocrinology, Tan Tock Seng Hospital, Singapore.
13
Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore.
14
Institute for Social Medicine, Epidemiology and Health Economics, Charite University Medical Centre, Berlin, Germany.

Abstract

AIM:

To examine the associations of physical activity and screen time, a proxy for sedentary behaviour, with fasting and post-load glucose levels in Singaporean women enrolled in a multi-ethnic Asian preconception study.

METHODS:

Moderate and vigorous physical activity and screen time (television and other electronic devices) were self-reported by women enrolled in the S-PRESTO cohort. Fasting, 30-min and 120-min glucose levels before and during a 75-g oral glucose tolerance test were measured. Associations of physical activity and screen time with glucose levels were analysed using multivariable linear marginal regression.

RESULTS:

A total of 946 women aged 31.4±3.7 years were examined, of whom 72% were of Chinese, 15.5% were of Malay, 9.3% were of Indian and 3.2% were of mixed ethnicity. A total of 32% of women reported being active, 36% watched television ≥2 h/day and 26% used electronic devices ≥3 h/day. In adjusted models, vigorous, but not moderate, physical activity was associated with lower overall glucose levels, and was associated more strongly with post-challenge than fasting glucose levels. Compared to women not engaging in vigorous physical activity, those engaging in physical activity ≥75 min/week had lower mean fasting [-0.14 (95% CI -0.28, -0.01) mmol/l], 30-min [0.35 (95% CI -0.68, -0.02) mmol/l] and 120-min [-0.53 (95% CI -0.16, -0.90) mmol/l] glucose levels (overall P value=0.05). We found no associations of screen time with glucose levels.

CONCLUSIONS:

Independently of the time spent in non-vigorous physical activity and using screens, engaging in vigorous physical activity may be a modifiable factor to improve glucose regulation in women of Asian ethnicity who are attempting to conceive.

PMID:
30888073
PMCID:
PMC6571076
[Available on 2020-01-01]
DOI:
10.1111/dme.13948

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