Format

Send to

Choose Destination
Osteoporos Int. 2019 Jul;30(7):1529-1531. doi: 10.1007/s00198-019-04925-8. Epub 2019 Mar 18.

Correlates of T50 and relationships with bone mineral density in community-living older men: the osteoporotic fractures in men (MrOS) study.

Author information

1
Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, CA, USA.
2
Department of Family Medicine and Public Health, University of California San Diego, San Diego, CA, USA.
3
Center to Improve Veteran Involvement in Care (CIVIC), VA Portland Health Care System, Portland, OR, USA.
4
Oregon Health & Science University School of Medicine, Portland, OR, USA.
5
Calciscon, Nidau, Biel, Switzerland.
6
Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, CA, USA. joeix@ucsd.edu.
7
Nephrology Section, Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA. joeix@ucsd.edu.

Abstract

PURPOSE:

T50 is a novel serum-based marker that assesses the propensity of calcification in serum. Shorter T50 indicates greater propensity to calcify and it has been associated to cardiovascular disease (CVD) and mortality among patients with kidney disease. In the general population, neither the correlates of T50 nor the relationships of T50 with bone mineral density (BMD) are known.

METHODS:

We performed a nested cross-sectional study selecting 150 individuals at random among participants from the Osteoporotic Fractures in Men (MrOS) Study, a study of community-living older men. We categorized individuals into tertiles of T50 and compared demographics and disease indicators across tertiles. We utilized linear regression to evaluate the cross-sectional association between T50 and hip and spine BMD in multivariable models.

RESULTS:

Older age was associated with shorter T50. Kidney function tended to be lower in those with shorter T50 and the prevalence of CVD and peripheral arterial disease in those with shorter T50, albeit these findings did not achieve statistical significance. We found no statistically significant associations between T50 and total hip or total spine BMD in either unadjusted or multivariable adjusted models.

CONCLUSIONS:

T50, a novel indicator of serum calcification propensity, is not associated with BMD in community-living older men. Future larger studies should determine if T50 may give insights to CVD in the general population above and beyond traditional risk factors.

KEYWORDS:

Bone mineral density; Calcification propensity score

PMID:
30887076
PMCID:
PMC6615942
[Available on 2020-07-01]
DOI:
10.1007/s00198-019-04925-8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center