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J Korean Med Sci. 2019 Mar 6;34(10):e78. doi: 10.3346/jkms.2019.34.e78. eCollection 2019 Mar 18.

Pathological Characteristics of Prostate Cancer in Men Aged < 50 Years Treated with Radical Prostatectomy: a Multi-Centre Study in Korea.

Author information

1
Department of Urology, International St. Mary's Hospital, Catholic Kwandong University, Incheon, Korea.
2
Department of Urology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea.
3
Department of Urology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
4
Department of Urology, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
5
Department of Urology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
6
Department of Urology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Abstract

Background:

Recently, younger prostate cancer (PCa) patients have been reported to harbour more favourable disease characteristics after radical prostatectomy (RP) than older men. We analysed young men (<50 years) with PCa among the Korean population, paying attention to pathological characteristics on RP specimen and biochemical recurrence (BCR).

Methods:

The multi-centre, Severance Urological Oncology Group registry was utilized to identify 622 patients with clinically localized or locally advanced PCa, who were treated with RP between 2001 and 2017. Patients were dichotomized into two groups according to age (< 50-year-old [n = 75] and ≥ 50-year-old [n = 547]), and clinicopathological characteristics were analysed. Propensity score matching was used when assessing BCR between the two groups.

Results:

Although biopsy Gleason score (GS) was lower in younger patients (P = 0.033), distribution of pathologic GS was similar between the two groups (13.3% vs. 13.9% for GS ≥ 8, P = 0.191). There was no significant difference in pathologic T stage between the < 50- and ≥ 50-year-old groups (69.3% vs. 68.0% in T2 and 30.7% vs. 32.0% in ≥ T3, P = 0.203). The positive surgical margin rates were similar between the two groups (20.0% vs. 27.6%, P = 0.178). BCR-free survival rates were also similar (P = 0.644) between the two groups, after propensity matching.

Conclusion:

Contrary to prior reports, younger PCa patients did not have more favourable pathologic features on RP specimen and showed similar BCR rates compared to older men. These findings should be considered when making treatment decisions for young Korean patients with PCa.

KEYWORDS:

Prognosis; Prostatectomy; Prostatic Neoplasms; Young Adults

PMID:
30886549
PMCID:
PMC6417998
DOI:
10.3346/jkms.2019.34.e78
[Indexed for MEDLINE]
Free PMC Article

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