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Plasmid. 2019 Mar;102:56-61. doi: 10.1016/j.plasmid.2019.03.002. Epub 2019 Mar 15.

Identification of a novel lineage of plasmids within phylogenetically diverse subclades of IncHI2-ST1 plasmids.

Author information

1
The Ithree Institute, University of Technology Sydney, City Campus, Ultimo, NSW 2007, Australia; NSW Department of Primary Industries, Elizabeth Macarthur Agricultural Institute, Sydney, Australia. Electronic address: Piklu.Bhattacharya@uts.edu.au.
2
The Ithree Institute, University of Technology Sydney, City Campus, Ultimo, NSW 2007, Australia.
3
Department of Microbiology and Infectious Diseases, Concord Hospital, NSW Health Pathology, Hospital Road, Concord 2139, NSW, Australia; Faculty of Medicine, University of Sydney, NSW, Australia.

Abstract

IncHI2-ST1 plasmids play an important role in co-mobilizing genes conferring resistance to critically important antibiotics and heavy metals. Here we present the identification and analysis of IncHI2-ST1 plasmid pSPRC-Echo1, isolated from an Enterobacter hormaechei strain from a Sydney hospital, which predates other multi-drug resistant IncHI2-ST1 plasmids reported from Australia. Our time-resolved phylogeny analysis indicates pSPRC-Echo1 represents a new lineage of IncHI2-ST1 plasmids and show how their diversification relates to the era of antibiotics.

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