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Int J Mol Sci. 2019 Mar 17;20(6). pii: E1345. doi: 10.3390/ijms20061345.

Plant Serine Protease Inhibitors: Biotechnology Application in Agriculture and Molecular Farming.

Author information

1
Instituto Tecnológico Chascomús (INTECH), UNSAM-CONICET, Chascomús, Provincia de Buenos Aires B7130, Argentina. mclemente@intech.gov.ar.
2
Instituto Tecnológico Chascomús (INTECH), UNSAM-CONICET, Chascomús, Provincia de Buenos Aires B7130, Argentina. marianacorigliano@intech.gov.ar.
3
Instituto Tecnológico Chascomús (INTECH), UNSAM-CONICET, Chascomús, Provincia de Buenos Aires B7130, Argentina. sebapariani@hotmail.com.
4
Instituto Tecnológico Chascomús (INTECH), UNSAM-CONICET, Chascomús, Provincia de Buenos Aires B7130, Argentina. esanchez@intech.gov.ar.
5
Instituto Tecnológico Chascomús (INTECH), UNSAM-CONICET, Chascomús, Provincia de Buenos Aires B7130, Argentina. valeriasander@intech.gov.ar.
6
Instituto Tecnológico Chascomús (INTECH), UNSAM-CONICET, Chascomús, Provincia de Buenos Aires B7130, Argentina. varamosd@intech.gov.ar.

Abstract

The serine protease inhibitors (SPIs) are widely distributed in living organisms like bacteria, fungi, plants, and humans. The main function of SPIs as protease enzymes is to regulate the proteolytic activity. In plants, most of the studies of SPIs have been focused on their physiological role. The initial studies carried out in plants showed that SPIs participate in the regulation of endogenous proteolytic processes, as the regulation of proteases in seeds. Besides, it was observed that SPIs also participate in the regulation of cell death during plant development and senescence. On the other hand, plant SPIs have an important role in plant defense against pests and phytopathogenic microorganisms. In the last 20 years, several transgenic plants over-expressing SPIs have been produced and tested in order to achieve the increase of the resistance against pathogenic insects. Finally, in molecular farming, SPIs have been employed to minimize the proteolysis of recombinant proteins expressed in plants. The present review discusses the potential biotechnological applications of plant SPIs in the agriculture field.

KEYWORDS:

molecular farming; pathogen resistance; plants; serine protease inhibitors

PMID:
30884891
PMCID:
PMC6471620
DOI:
10.3390/ijms20061345
[Indexed for MEDLINE]
Free PMC Article

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