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Cancer Biomark. 2019;24(3):269-277. doi: 10.3233/CBM-182216.

Long non-coding RNA MAGI2-AS3 inhibits breast cancer cell migration and invasion via sponging microRNA-374a.

Du S1,1, Hu W2,3,1, Zhao Y4, Zhou H1, Wen W1, Xu M5, Zhao P6, Liu K3,6.

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Zibo Vocational Institute, Zibo, Shandong 255314, China.
Department of Breast and Thyroid Surgery, Zibo Central Hospital, Zibo, Shandong 255036, China.
Zibo City Key Laboratory of Individualized Diagnosis and Transformation of Breast Cancer, Zibo Central Hospital, Zibo, Shandong 255036, China.
School of Stomatology, Shandong University, Jinan, Shandong 250012, China.
The Seventh People's Hospital of Zibo, Zibo, Shandong 255040, China.
Center of Translational Medicine, Zibo Central Hospital, Zibo, Shandong 255036, China.


Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts that play important roles in tumorigenesis and tumor progression. Our study aimed to explore the role of lncRNA MAGI2-AS3 in breast cancer metastatic progression. In the present study, our results showed that MAGI2-AS3 can inhibit the migration and invasion of breast cancer cells. In addition, an increase in MAGI2-AS3 can inhibit microRNA-374a (miR-374a) expression in breast cancer cells. Bioinformatic analysis predicted the correlation between MAGI2-AS3 and miR-374a. Phosphatase and tensin homolog (PTEN) was found to be an novel mRNA target of miR-374a. MAGI2-AS3 upregulation inhibited breast cancer metastatic progression by decreasing miR-374a and enhancing PTEN expression. Together, our data revealed that lncRNA MAGI2-AS3 is involved in breast cancer cell progression by regulating the miR-374a-PTEN axis. These findings offer new insight into treatment strategies for breast cancer.


PTEN; breast cancer; invasion; lncRNA MAGI2-AS3; miR-374a; migration


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