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Cancer Biomark. 2019;24(3):269-277. doi: 10.3233/CBM-182216.

Long non-coding RNA MAGI2-AS3 inhibits breast cancer cell migration and invasion via sponging microRNA-374a.

Du S1,1, Hu W2,3,1, Zhao Y4, Zhou H1, Wen W1, Xu M5, Zhao P6, Liu K3,6.

Author information

1
Zibo Vocational Institute, Zibo, Shandong 255314, China.
2
Department of Breast and Thyroid Surgery, Zibo Central Hospital, Zibo, Shandong 255036, China.
3
Zibo City Key Laboratory of Individualized Diagnosis and Transformation of Breast Cancer, Zibo Central Hospital, Zibo, Shandong 255036, China.
4
School of Stomatology, Shandong University, Jinan, Shandong 250012, China.
5
The Seventh People's Hospital of Zibo, Zibo, Shandong 255040, China.
6
Center of Translational Medicine, Zibo Central Hospital, Zibo, Shandong 255036, China.

Abstract

Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts that play important roles in tumorigenesis and tumor progression. Our study aimed to explore the role of lncRNA MAGI2-AS3 in breast cancer metastatic progression. In the present study, our results showed that MAGI2-AS3 can inhibit the migration and invasion of breast cancer cells. In addition, an increase in MAGI2-AS3 can inhibit microRNA-374a (miR-374a) expression in breast cancer cells. Bioinformatic analysis predicted the correlation between MAGI2-AS3 and miR-374a. Phosphatase and tensin homolog (PTEN) was found to be an novel mRNA target of miR-374a. MAGI2-AS3 upregulation inhibited breast cancer metastatic progression by decreasing miR-374a and enhancing PTEN expression. Together, our data revealed that lncRNA MAGI2-AS3 is involved in breast cancer cell progression by regulating the miR-374a-PTEN axis. These findings offer new insight into treatment strategies for breast cancer.

KEYWORDS:

PTEN; breast cancer; invasion; lncRNA MAGI2-AS3; miR-374a; migration

PMID:
30883342
DOI:
10.3233/CBM-182216

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