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Pediatr Infect Dis J. 2019 Apr;38(4):396-397. doi: 10.1097/INF.0000000000002167.

Impact of Trimethoprim-sulfamethoxazole Urinary Tract Infection Prophylaxis on Non-UTI Infections.

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From the Division of Hospital Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati OH.
Division of Infectious Diseases in the Departments of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.


In this secondary analysis of the Randomized Intervention for Children with Vesicoureteral Reflux cohort, we found that daily prophylaxis with trimethoprim-sulfamethoxazole was not associated with an increased or decreased risk of skin and soft tissue infections, pharyngitis or sinopulmonary infections in otherwise healthy children 2-71 months of age.

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