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Anesth Pain Med. 2019 Jan 8;9(1):e85279. doi: 10.5812/aapm.85279. eCollection 2019 Feb.

Meeting Between Rumi and Shams in Notch Signaling; Implications for Pain Management: A Narrative Review.

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Immunology Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Cardiac Anesthesiology Department, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


The meeting between Rumi and Shams, in the 13th century, was a turning point in the life of Rumi leading to a revolutionary effect in his thoughts, ideas, and poems. This was an ever-inspiring meeting with many results throughout the centuries. This meeting has created some footprints in cellular and molecular medicine: The discovery of two distinct genes in Drosophila, i.e. Rumi and Shams and their role in controlling Notch signaling, which has a critical role in cell biology. This nomination and the interactions between the two genes has led us to a number of novel studies during the last years. This article reviews the interactions between Rumi and Shams and their effects on Notch signaling in order to find potential novel drugs for pain control through drug development studies in the future.


Drosophila; Drug Development; Notch Signaling; Pain; Rumi; Shams

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