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Cancer Manag Res. 2019 Feb 27;11:1907-1920. doi: 10.2147/CMAR.S184970. eCollection 2019.

Pretreatment lymphocyte-to-monocyte ratio as a predictor of survival among patients with ovarian cancer: a meta-analysis.

Author information

1
Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong, China, zengffjnu@126.com.
2
Department of Nutrition, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.
3
Department of Nutrition, School of Medicine, Jinan University, Guangzhou 510632, Guangdong, China.
4
Department of Medical Statistics, School of Medicine, Jinan University, Guangzhou 510632, Guangdong, China, zhusui1213@126.com.

Abstract

Introduction:

In this meta-analysis, we analyzed retrospective cohort studies that assessed the prognostic potential of the pretreatment lymphocyte-to-monocyte ratio (LMR) among patients with ovarian cancer (OC).

Materials and methods:

We comprehensively searched electronic databases, including PubMed and Embase, from inception through October 2018. A random-effects model was used to calculate pooled HRs and their 95% CIs for overall survival (OS) and progression-free survival (PFS). The low LMR group was treated as the reference group.

Results:

Twelve studies, including 3,346 OC cases at baseline, were included. Overall, our results indicated that LMR was positively associated with both OS (HR: 1.85, 95% CI: 1.50-2.28, P<0.001; I 2=76.5%) and PFS (HR: 1.70, 95% CI: 1.49-1.94, P<0.001; I 2=24.4%) among OC patients. Stratified analyses indicated that, for OS, the LMR's protective effect was more evident in studies conducted among younger patients (<55 years) than in those conducted among older patients (≥55 years; P for interaction =0.017), which was confirmed by meta-regression analysis (P=0.004).

Conclusion:

This study suggested that a higher pretreatment LMR level was associated with a favorable prognosis among OC patients. Future large-scale prospective clinical trials are needed to confirm the prognostic value of LMR among OC patients.

KEYWORDS:

lymphocyte-to-monocyte ratio; meta-analysis; ovarian cancer; prognosis

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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