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Eur J Plant Pathol. 2019;153(1):1-14. doi: 10.1007/s10658-018-01614-w. Epub 2018 Oct 29.

Small RNA molecules and their role in plant disease.

Author information

1
1Institut für Populationsgenetik, Heinrich-Heine-Universität, Universitätsstraße 1, 40225 Düsseldorf, Germany.
2
2Laboratory of Phytopathology, Wageningen University, P.O. Box 16, Wageningen, 6700 AA The Netherlands.
3
3Laboratory of Cell Biology, Wageningen University, P.O. Box 633, Wageningen, 6700 AP The Netherlands.
4
4Keygene N.V, Agro Business Park 90, 6708 PW Wageningen, The Netherlands.

Abstract

All plant species are subject to disease. Plant diseases are caused by parasites, e.g. viruses, bacteria, oomycetes, parasitic plants, fungi, or nematodes. In all organisms, gene expression is tightly regulated and underpins essential functions and physiology. The coordination and regulation of both host and pathogen gene expression is essential for pathogens to infect and cause disease. One mode of gene regulation is RNA silencing. This biological process is widespread in the natural world, present in plants, animals and several pathogens. In RNA silencing, small (20-40 nucleotides) non-coding RNAs (small-RNAs, sRNAs) accumulate and regulate gene expression transcriptionally or post-transcriptionally in a sequence-specific manner. Regulation of sRNA molecules provides a fast mode to alter gene activity of multiple gene transcripts. RNA silencing is an ancient mechanism that protects the most sensitive part of an organism: its genetic code. sRNA molecules emerged as regulators of plant development, growth and plant immunity. sRNA based RNA silencing functions both within and between organisms. Here we present the described sRNAs from plants and pathogens and discuss how they regulate host immunity and pathogen virulence. We speculate on how sRNA molecules can be exploited to develop disease resistant plants. Finally, the activity of sRNA molecules can be prevented by proteins that suppress RNA silencing. This counter silencing response completes the dialog between plants and pathogens controlling plant disease or resistance outcome on the RNA (controlling gene expression) and protein level.

KEYWORDS:

Epigenetics; Plant immunity; Plant-pathogen interaction; RNA silencing

Conflict of interest statement

Author L.E.R declares that she has no conflict of interest. Author E.J.R.O declares that she has no conflict of interest. Author M.v.D declares that she has no conflict of interest.This article does not contain any studies with human participants or animals performed by any of the authors.

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