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Geburtshilfe Frauenheilkd. 2019 Mar;79(3):281-285. doi: 10.1055/a-0746-8985. Epub 2019 Mar 12.

Female Adnexal Tumour of Probable Wolffian Origin (FATWO): Review of the Literature.

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Department of Obstetrics and Gynaecology, Würzburg University Medical Centre, Würzburg, Germany.
Department of Pathology, Universitiy of Würzburg and Comprehensive Cancer Center (CCC) Mainfranken, Würzburg, Germany.
Institute of Pathology, Ludwig-Maximilians-University Munich, Munich, Germany.
Department of Diagnostic Radiology, Würzburg University Medical Centre, Würzburg, Germany.


in English, German

FATWO (female adnexal tumour of probable Wolffian origin) denotes a rare tumour of the female adnexa which has been described in nearly 80 cases worldwide and which presumably originates in the remains of the Wolffian ducts. In 10 to 20 percent of patients, a metastasis or recurrence was seen subsequently and for this reason, a malignant potential is attributed to the FATWO. Because of the small number of cases, there is no clear therapeutic recommendation. The method of choice currently is surgical treatment with hysterectomy and adnexectomy. The benefit of radio- and chemotherapies is not clear and a small number of treatment attempts with imatinib have been made in cases of CD117 positivity or treatment attempts on an endocrine basis. This work provides an overview of the literature on epidemiology, imaging and histopathological diagnostic features as well as therapeutic options of this same tumour form.


FATWO; adnexal tumour; borderline tumour

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