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Indian J Med Microbiol. 2018 Oct-Dec;36(4):587-589. doi: 10.4103/ijmm.IJMM_18_293.

Deciphering polymyxin B minimum inhibitory concentration from colistin minimum inhibitory concentration and vice versa: An analysis on 156 carbapenem-resistant Enterobacteriaceae isolates.

Author information

1
Department of Microbiology, AIIMS, Bhubaneswar, Odisha, India.

Abstract

The susceptibility determination to polymyxins (colistin and polymyxin B) remains a challenge for clinical microbiology laboratories. We evaluated the minimum inhibitory concentration (MIC) of both antimicrobials by the broth microdilution method in a selected subset of 156 carbapenem-resistant Enterobacteriaceae (CRE) isolates. Good concordance between polymyxin B and colistin MIC values was obtained, and there was 98% categorical agreement in CRE isolates. Future large-scale multicentre study is needed to draw conclusion if the MIC of colistin can be used to extrapolate the MIC of polymyxin B and vice versa.

KEYWORDS:

Broth microdilution method; Colistin; Minimum inhibitory concentration; carbapenem-resistant Enterobacteriaceae; polymyxin B

PMID:
30880712
DOI:
10.4103/ijmm.IJMM_18_293

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