Format

Send to

Choose Destination
Drug Discov Ther. 2019;13(1):38-46. doi: 10.5582/ddt.2019.01004.

Effects of coenzyme Q10 supplementation on diastolic function in patients with heart failure with preserved ejection fraction.

Author information

1
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Diponegoro University.
2
Department of Pharmacology and Therapeutics, Faculty of Medicine, Diponegoro University.
3
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University.

Abstract

Heart failure with preserved ejection fraction (HFpEF) is a leading cause of morbidity and mortality without an established treatment. Diastolic dysfunction, the hallmark of HFpEF, is associated with altered myocardial bioenergetics. No previous study has examined the effects of coenzyme Q10 (CoQ10) on left ventricle (LV) diastolic function in patients with HFpEF. We investigated whether CoQ10 could improve LV diastolic function in patients with HFpEF. We performed a randomized controlled trial (RCT) using pretest and posttest control groups of 30 patients with HFpEF. The patients received either CoQ10 100 mg three times a day or no CoQ10 in addition to routine treatment for 30 days. Echocardiographic study was performed at baseline and follow-up. LV diastolic function was evaluated by two dimensional and Doppler echocardiography as follows; average E/e׳, septal and lateral e׳velocity, and left atrium volume index (LAVI). A total of 28 patients completed the study. A statistically significant improvement was observed in the CoQ10 treatment group in terms between groups (∆E/e׳ ‒ 3.6 vs. ‒ 2.4; p = 0.28) and (∆LAVI ‒ 5.4 vs. ‒ 4.4; p = 0.83). Short term CoQ10 supplementation provided no additional benefits in improving LV diastolic function in patients with HFpEF.

KEYWORDS:

Heart failure with preserved ejection fraction (HFpEF); LV diastolic function; coenzyme Q10

PMID:
30880321
DOI:
10.5582/ddt.2019.01004
Free full text

Supplemental Content

Full text links

Icon for J-STAGE, Japan Science and Technology Information Aggregator, Electronic
Loading ...
Support Center