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Clin Gastroenterol Hepatol. 2019 Mar 15. pii: S1542-3565(19)30272-1. doi: 10.1016/j.cgh.2019.03.008. [Epub ahead of print]

Sustained Remission of Eosinophilic Esophagitis Following Discontinuation of Dietary Elimination in Children.

Author information

1
Institute of Gastroenterology, Nutrition, and Liver Diseases, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
2
Division of Gastroenterology and Hepatology, First Department of Pediatrics, University of Athens, Children's Hospital "Agia Sofia", Athens, Greece.
3
Pediatric Gastroenterology Unit, University Hospital Puerta de Hierro-Majadahonda, Madrid, Spain.
4
Gastroenterology and Nutrition Department, Niño Jesús University Children Hospital, Madrid, Spain.
5
Pediatrics, Gelre Hospitals, Apeldoorn, The Netherlands.
6
First Department of Pediatrics, University of Athens School of Medicine, Mitera Children's Hospital, Athens, Greece.
7
Pediatric Gastroenterology Unit, Centro Hospitalar São João, Porto, Portugal.
8
Department of Pediatrics, Sapienza University of Rome, Rome, Italy.
9
Nutrition and Dietetics Department, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
10
Institute of Gastroenterology, Nutrition, and Liver Diseases, Schneider Children's Medical Center of Israel, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: nzevit@gmail.com.

Abstract

Eosinophilic esophagitis (EoE), when left untreated, may progress from an inflammatory to a fibrostenotic phenotype. Inflammation generally recurs after treatment withdrawal. Thus, long-term treatment has been recommended. Here, we describe a cohort of children with EoE who achieved clinical and histologic remission with elimination diets, and maintained sustained untreated remission (SUR) despite re-introduction of all eliminated food allergens.

PMID:
30880275
DOI:
10.1016/j.cgh.2019.03.008

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