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Carbohydr Polym. 2019 Jun 1;213:128-137. doi: 10.1016/j.carbpol.2019.02.064. Epub 2019 Feb 19.

Redispersible Pickering emulsion powder stabilized by nanocrystalline cellulose combining with cellulosic derivatives.

Author information

1
Jiangxi University of Traditional Chinese Medicine, 818 Meilingdadao Road, Nanchang 330004, China.
2
Jiangxi University of Traditional Chinese Medicine, 818 Meilingdadao Road, Nanchang 330004, China; Department of Pharmaceutics, 908th Hospital of People's Liberation Army, Nanchang, China.
3
Jiangxi University of Traditional Chinese Medicine, 818 Meilingdadao Road, Nanchang 330004, China. Electronic address: feigleyue@outlook.com.

Abstract

The objective of this study is to use cellulose nanocrystals (CNC) combining with carboxymethyl cellulose sodium (CMC-Na) and hydroxypropyl methylcellulose (HPMC) as stabilizer to prepare novel redispersible camellia oil Pickering emulsions powder (CO-PEP). Cellulose nanocrystals modified with carboxymethyl cellulose sodium (CNCC) was prepared by homogenization technology. CNCC seemed to be rod-like particles with mean particle size of 124.2 ± 2.5 nm. And the cellulose structure, crystal state and thermal property of CNCC remained unchanged during the homogenization. The combination of CNC and CMC-Na in CNCC might be dependent of physical interaction. The mean particle size of optimum CO-PE/0.25%CNCC was 0.569 ± 0.023 μm. The CNCC based particle stabilizer might form the distinctive barrier layer around oil droplet. The redispersibility results demonstrated that 50% HPMC based CO-PEP formed large composite particle with high drug loading ability and exhibited superior redispersibility. Novel redispersible powdered Pickering emulsions could be prepared by cellulose nanocrystals combining with water-soluble cellulosic derivatives.

KEYWORDS:

Carboxymethyl cellulose sodium; Cellulose nanocrystals; Homogenization; Hydroxypropyl methylcellulose; Redispersible Pickering emulsions

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