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Apoptosis. 2019 Jun;24(5-6):529-537. doi: 10.1007/s10495-019-01531-1.

Improved in vivo targeting of BCL-2 phenotypic conversion through hollow gold nanoshell delivery.

Author information

1
Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, USA. emorgan@chem.ucsb.edu.
2
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
3
Linus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA.
4
Center for Genome Research and Biocomputing, Oregon State University, Corvallis, OR, 97331, USA.
5
Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, USA. reich@chem.ucsb.edu.

Abstract

Although new cancer therapeutics are discovered at a rapid pace, lack of effective means of delivery and cancer chemoresistance thwart many of the promising therapeutics. We demonstrate a method that confronts both of these issues with the light-activated delivery of a Bcl-2 functional converting peptide, NuBCP-9, using hollow gold nanoshells. This approach has shown not only to increase the efficacy of the peptide 30-fold in vitro but also has shown to reduce paclitaxel resistant H460 lung xenograft tumor growth by 56.4%.

KEYWORDS:

Apoptosis; Bcl-2; Hollow gold nanoshells; NuBCP; Peptide delivery; Resistant cancer

PMID:
30879165
DOI:
10.1007/s10495-019-01531-1

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