Format

Send to

Choose Destination
Bioorg Chem. 2019 Mar 9;87:56-69. doi: 10.1016/j.bioorg.2019.03.017. [Epub ahead of print]

Development of novel 2-substituted acylaminoethylsulfonamide derivatives as fungicides against Botrytis cinerea.

Author information

1
College of Plant Protection, Shenyang Agricultural University, Shenyang 110866, China.
2
College of Science, China Agricultural University, Beijing 100091, China.
3
College of Plant Protection, Shenyang Agricultural University, Shenyang 110866, China. Electronic address: xinghai30@163.com.

Abstract

Botrytis cinerea is an economically important fungal pathogen with a host range of over 200 plant species. Unfortunately, gray mold disease caused by B. cinerea has not been effectively controlled because of its high risk for fungicide resistance development. As a part of our ongoing efforts to develop novel sulfonamides as agricultural fungicides against Botrytis cinerea, we introduced 2-aminoethanesulfonic acid (taurine) substructure, designed and synthesized a series of novel 2-substituted acylaminoethylsulfonamides. The newly synthesized sulfonamides were evaluated in vitro and in vivo for their fungicidal activity against Botrytis cinerea, of which the 2-ethoxyacetylamide derivative (V-A-12, EC50 = 0.66 mg·L-1) exhibited the highest potency in vitro and superior fungicidal activity compared with procymidone (EC50 = 1.06 mg·L-1). In vivo bioassay indicated that compound V-A-12 could be effective for the control of tomato gray mold. Moreover, the structure-activity relationship of these sulfonamides was analyzed by establishing a three-dimensional quantitative structure-activity relationship (3D-QSAR) model, which can provide guidance for the development of sulfonamides as fungicides. Finally, the effeicacy of sulfonamide derivatives was again verified in the activity evaluation against resistant Botrytis cinerea strains. These results further enhance the development value of 2-substituted acylaminoethylsulfonamides to control the tomato gray mold.

KEYWORDS:

3D-QSAR; Botrytis cinerea; Fungicidal activities; Sulfonamides; Taurine

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center