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J Rheumatol. 2019 Mar 15. pii: jrheum.180832. doi: 10.3899/jrheum.180832. [Epub ahead of print]

Synovial perfusion assessed by dynamic contrast-enhanced MRI is associated to treatment response, remission, and cartilage quality in rheumatoid arthritis.

Author information

1
From the Department and Hiller-Research-Unit for Rheumatology and Department of Diagnostic and Interventional Radiology, Heinrich-Heine-University Düsseldorf, Medical Faculty, , 40225 Dusseldorf, Germany. Address correspondence to. Dr. Philipp Sewerin, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology, Moorenstrasse 5, 40225 Duesseldorf, Germany, E-mail: philipp.sewerin@med.uni-duesseldorf.de.

Abstract

OBJECTIVE:

To assess associations of synovial perfusion, cartilage quality and outcome in rheumatoid arthritis (RA).

METHODS:

Synovial perfusion and cartilage quality were assessed by dynamic contrastenhanced magnetic resonance imaging in metacarpophalangeal joints of 28 treatment-naïve RA patients at baseline, 3 and 6 months after methotrexate. Analysis was by linear mixed modelling.

RESULTS:

Synovial perfusion parameters were associated to remission (p<0.05) and cartilage quality (p<0.004). Maximum synovial enhancement was associated to EULAR response (p<0.05). Synovial perfusion improved in non-responders over time (p<0.05).

CONCLUSION:

Synovial perfusion relates to remission, response, and cartilage quality in a cohort of therapy naïve, early RA patients.

PMID:
30877219
DOI:
10.3899/jrheum.180832

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